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On the path from scientific discovery to new drug, the clinical trial is a huge — and critical — hurdle. Clinical trials are themselves experiments, and to make sure that they are doing the best possible job at deter...
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The FDA recently approved the first prescription video game. The a16z bio Journal Club covers one of the key clinical trials that supported this FDA decision and discusses the evidence showing that this game can have a measurable impact on the attention impairments seen in children with ADHD.
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If the best way to know whether a medicine is effective is through a clinical trial, then where does (and doesn't) real-world data and real-world evidence come in? The topic is always top of mind in drug development, with additional focus as of 2016 thanks to the 21st Century Cures Act -- but is especially heated lately given recent concerns and claims around particular drugs in the context of the novel coronavirus pandemic. So in this short-but-deep dive episode of 16 Minutes on the News, a16z general partner in bio Vijay Pande -- previously a professor of Chemistry, Structural Biology, and Computer Science at Stanford University (as well as founder of Folding@Home) -- breaks down the debate between RWE vs. RCT (real world evidence and randomized controlled trials), in conversation with Sonal Chokshi.
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Editor’s note: This article is based on an episode of the a16z Podcast, which you can listen to here.
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Veterinary oncology can inform human oncology, and vice versa — providing a better model for looking at drug performance, interrelationships, and more. Especially when you add in data (there’s no “doggy...
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On average, only 1 out of 20 medicines works when we actually bring them into the human body, and these rates of success haven’t moved much in the pharma industry overall in the past 15 years, despite much scientif...