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If these modalities have proven to be so effective (in some cases, even curative) against cancer, is there a role for them outside oncology, in the treatment of chronic diseases that might also be driven by a population of bad-actor cells? Arda Therapeutics is building upon exactly this bold hypothesis.
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Braintrust is a devtool platform for any product effort — from simple apps to sophisticated products — based around large language models.
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As the market-leading AI scribe for veterinarians, Scribenote automates burdensome documentation requirements.
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GCTx is flipping the entire iPSC differentiation paradigm on its head. Rather than manually iterating through a limited set of differentiation protocols, the Human TFome technology platform instead deploys large-scale combinatorial screening to discover new hypotheses and new protocols that are as-yet unknown to even the best biologists.
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Fei-Fei Li and are team of experts at World Labs are building a spatial intelligence model that can generate 3D worlds that users can interact with.
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Mintlify lets companies publish quality software documentation that aligns with their brands, including guides, API reference, and examples.
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Pylon provides a single view of customer issues, wherever they are happening — Slack, Teams, chat widget, ticket forms, or emails.
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Cursor is a fork of VS Code that’s heavily customized for AI-assisted programming, with loads of features designed to integrate AI into developer workflows.
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We're excited to announce our investment in Black Forest Labs (BFL), which is building the world’s best open visual models for developers.
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Daylight is building a decentralized protocol to fund and coordinate distributed energy resources.
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a16z is proud to lead Saronic’s Series B and continue supporting founder and CEO Dino Mavrookas and his team of engineers, veterans, and operators.
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We are entering the new SaaS era, moving from Software-as-a-Service to Service-as-a-Software.
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The Little Tech AgendaFeatured
The time has come to stand up for Little Tech. Bad government policies are now the #1 threat to Little Tech. We believe American technology supremacy, and the critical role that Little Tech startups play in ensuring that supremacy, is a first class political issue on par with any other.
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Here's where AI agents and software can have the most immediate impact on your business, and make you more efficient and productive.
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Pharma represents one of the biggest industries in the world. The top 10 pharma companies account for over $3.4T in aggregate market cap, and last year, the US alone spent more than $700B on pharmaceuticals and prescript...
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We’re excited to share that we’re investing in k-ID - the best-in-class compliance engine for online safety and privacy management.
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Recently, we invested in Function Health, a company that embodies the vision and excitement we had when writing those theses. The one piece we underestimated is the current state of latent demand among consumers for a new approach to healthcare and longevity.
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This medical home is exactly what knownwell is building – and scaling. Through a hybrid virtual and in-person care model, knownwell offers both primary care as well as longitudinal specialty care, inclusive of weight management, diabetes care, medication (and side effect) management, multi-disciplinary nutritional counseling, and behavioral health services.
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a16z is excited to invest in Decagon, an AI agent that automates customer support for a business, and to have led their seed round.
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Talkiatry addresses the acute end of the behavioral health market—psychiatric care—by offering virtual treatment covered by patients’ insurance.
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There is perhaps nowhere more exciting or impactful to build such tools than in healthcare—where progress is often so constrained by human expertise. Valar Labs is taking on exactly this challenge, and bringing AI into the toolbox for better cancer care.
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We're thrilled to lead the $5M seed round for Yellow, a company focused on revolutionizing 3D character creation through generative AI.
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The opportunity to build the next iconic cybersecurity platform has arrived: Wiz, a global leader in cloud-native security.
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We have just raised $7.2B for American Dynamism ($600M), Apps ($1B), Games ($600M), Infrastructure ($1.25B), and Growth ($3.75B). This marks an important milestone for us.
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Tennr understands unstructured inputs, applying AI reasoning and decision-making to perform complex end-to-end workflows.
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We’re excited to partner with the Espresso team to help bring to life a more seamless and interoperable future for Ethereum.
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We’re excited to announce A16Z GAMES' investment in Kaedim, a new type of co-development platform providing AI-powered art outsourcing.
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The release of the latest Ideogram.ai model is a massive step forward for image models. We're excited to lead their Series A.
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It's a pleasure to announce that we're leading EigenLayer's Series B. We're excited to partner with founder Sreeram Kannan and the whole team on building a platform that unlocks a new dimension of open innovation on top of Ethereum.
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Tigris has built a globally available S3-compatible distributed object-storage service that makes the application developer’s job as simple as possible.
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Upstash powers caching and messaging for tens of thousands of production applications across four different products, including many AI applications.
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As students of financial markets, we’re keenly interested in moments of inflection which alter market structure, spawn dominant new institutions, and catalyze the growth of new asset classes. Historically, these shifts h...
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There comes a point after 12 years where you either double down or figure something else out. I’m still a loyal a16zer but will embark on something new.
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Doppel is building a next-generation approach for detecting and removing fraudulent accounts and phishing attacks across various channels.
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Over the past decade, data infrastructure across industries has been modernized by many disruptors like Databricks, Fivetran, et al. The modern data stack has made it much easier for companies to ingest, store, query, an...
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What will it take for AI to go mainstream with consumers? Effective model aggregation, a better UI, and a powerful platform for creators. Enter Poe.
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Luma AI is building fast, high-quality, and deployable foundation models that let anyone create interactive 3D assets based on text prompts.
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Distributional is building a platform for robust and repeatable testing of AI and machine learning models so teams can push to prod confidently.
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Politics and the FutureFeatured
If a candidate supports an optimistic technology-enabled future, we are for them. If they want to choke off important technologies, we are against them
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Tome is launching with over $200 million to advance its PGI platform to focus on in vivo and ex vivo applications, with support from a16z Bio + Health, ARCH, GV, Longwood, Polaris and other leading investors. First up on Tome’s in vivo surgical slate: monogenic diseases of the liver. On the ex vivo cell engineering front, Tome is using PGI to rewire cells to cure common, chronic diseases—an area of great promise—with an initial focus on B-cell driven autoimmune diseases.
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Mistral is at the center of the open source AI developer community. This is the most promising path to achieve robust and trusted AI systems.
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Air Space Intelligence is a modern aerospace company addressing the software crisis in aerospace in both the enterprise and government sectors.
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Smart energy grids. Voice-first companion apps. Programmable medicines. AI tools for kids. We asked over 40 partners across a16z to preview one big idea they believe will drive innovation in the coming year.
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While most small molecule drugs bind and inhibit the disease-causing activity of their (typically intracellular) protein targets, Gate Bio instead attacks harmful extracellular proteins by eliminating them at their very root: right where they are produced and secreted from the cell.
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911 call centers – also known as public safety answering points (PSAPs) – are one of the most actively used public-safety infrastructure systems in the United States, fielding an estimated 240 million calls per year. Tha...
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The Techno-Optimist ManifestoFeatured
We are told that technology is on the brink of ruining everything. But we are being lied to, and the truth is so much better. Marc Andreessen presents his techno-optimist vision for the future.
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Led by CEO and Founder Ben Leventhal, Blackbird seeks to reward and delight consumers with elevated dining experiences, powered and personalized by web3.
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Insights from leaders at OpenAI, Microsoft, Anthropic, Databricks, Character.AI, Roblox, insitro, and Figma on where we are, where we're going, and the open questions for building the next wave of AI.
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We’re leading a Seed investment in Proof of Play, an on-chain game studio and tech company that’s committed to building a future with composability, interoperability, and permanence at the core of gameplay.
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TipTop creates tools that reduce the consumer code of owning products. They offer customers a guaranteed buyback price at the time of purchase, so they only pay for the product while they need it.
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a16z will lead the Series A of Moment, a new company building infrastructure that abstracts away the complexities of embedding fixed income investments in any application.
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These founders are tackling big challenges ranging from improving wellness through video games to addressing absenteeism in K-12 schools through a learn-to-earn model to delivering affordable internet service to underserved communities.
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In this episode of Zone of Genius, we explore our cultural connection to sports.
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Evolve or Die: The Future of the Creative Process, Artist Authenticity, and the Value of the MusicFeatured
In the first episode of the Cultural Leadership Fund’s Zone of Genius series, we sit down with leaders in music, Doug E. Fresh, Dre Lyon, Nicole Wyskoarko, and Piff Marti.
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Guests Julia Collins, Nyesha Arrington, and Alvin Salehi sit down with the Cultural Leadership Fund to share their insights about our ties to food. From comfort and safety to supply chain to the only way to make a proper mac n cheese, explore the many ways technology and the food industry impacts what we eat.
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Socket monitors open source packages for the most important security issues, covering the spectrum of risk across the software supply chain.
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We’re thrilled to announce Anjney Midha will be joining a16z as a general partner to lead our growing AI efforts.
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As we strive to find and support the most ambitious life sciences founders, we also work to connect these founders with exceptional advisors who have traveled the journey before.
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Apex’s flagship Aries platform satellite bus is being manufactured for scale, targeting both commercial and defense companies where speed is critical.
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ElevenLabs is on a mission to give every program a voice through its proprietary speech synthesis, voice design, and cloning technology
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Over the last year it has become clear that blockchains and the software movement around them -- usually called crypto or web3 -- can only succeed with a clear regulatory regime that provides an open pathway for startups...
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As we have seen the Pomelo team build out their virtual clinic, care model, and software platform, they are dedicated to a few key principles which we believe are absolutely critical to building a scalable company in this space.
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There's a full-blown moral panic about AI right now. But the real risk is losing the race to global AI technological superiority.
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A curated list of resources we’ve relied on to get smarter about modern AI, including generative AI, LLMs, and transformer models.
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The very nature of generative AI—conversational, scalable, accessible to non-technical users—has the potential to solve the shortcomings of previous generations of rules-based chatbots and other such products in making these concepts a reality.
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Hear from a16z CLF's nonprofit partners and leaders about their organizations' work and why technology represents a meaningful opportunity to advance Black wealth generation.
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We’re leading a $100 million Series B round in vector database provider Pinecone, to support its vision of becoming the memory layer for AI applications.
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Most people don’t know that nuclear energy — a clean, carbon-free energy source — accounts for 20% of electricity in the United States and over half of its carbon-free electricity. However, while large nuclear reactors a...
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Character AI is a platform, based on a proprietary LLM, for creating and chatting with different AI characters. We're leading their Series A!
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Years before the first blockchain was created, the sci-fi space MMO EVE Online proved out many of the core principles that define web3 today. This is why we are excited to be partnering with CCP on a new project set in t...
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Understanding what’s in an image — one of the simplest cognitive tasks for most humans — is a stubbornly difficult problem for artificial intelligence systems to solve.
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The contractor payroll market is massive. Roughly one-third of U.S. workers have performed freelance work in the last year, and $1.4 trillion is paid out to contract workers annually. In many ways, contractors are the ba...
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There is a moment of wonder in every great game that makes you sit back, take a breath, and really appreciate what it is that you’re experiencing: stepping out into the world of Zelda, overcoming Margit for the first tim...
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Every so often, we meet founders with unusually strong conviction about solving systems problems. They’ve often lived through the pain of bad software, diagnosed the cause of their suffering, and made it their mission to...
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It’s very rare to see a new building block emerge in computing. If aliens landed on earth and decompiled our software, every app would look roughly the same: some combination of networking, storage, and compute. The way...
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Since kicking off the Talent x Opportunity (TxO) Initiative, we have invested in 27 companies building products and services based on unique cultural insights. The founders we backed and continue to support have taken tr...
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Every student can learn, just not on the same day, or the same way. – George Evans
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We are thrilled to announce that a16z Games has led the Series Seed investment in Snapser, a games backend technology company poised to become the de facto platform for games studios.
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In recent years, we’ve seen a renaissance in productivity software. To make knowledge work seamless, internal teams have largely moved off of “hard files,” toward real-time workspaces with commenting, collaboration, and...
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Debt is daunting—its labyrinth of complex rules, opaque governing bodies, and unique vernacular makes it difficult for the average consumer to understand. Concepts like credit scores, APRs, retroactive interest, and coll...
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We are thrilled to announce that a16z led the Series A investment in Voldex, a game studio that acquires, improves, and builds games on the massive user-generated content (UGC) platforms, Roblox and Minecraft.
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Cyber incidents have reached a crisis level over the past decade. In 2021, the U.S. saw 1,862 data compromises, affecting nearly 300 million people (a nearly 100% increase from five years ago). Cybersecurity practitioner...
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Within every era of technology, the most talented entrepreneurs have taken unsolved problems and open questions and turned them into businesses.
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In our quest to back exceptional founders effecting transformative change in our healthcare system, we recognize and embrace the need for partnership with “the system.” To do that well requires a deep understanding of th...
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We’re thrilled to announce that Andreessen Horowitz is leading the seed investment in Seidr AB who are building the next generation of midcore cross-play games. Based in Stockholm, a hotbed of games innovation, Seidr’s f...
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From entertainment franchise games to the precision delivery of medicines, small modular reactors to loads of AI applications, here are 40+ builder-worthy pursuits for 2023.
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Behind many of life’s most important financial transactions — be it buying a house, applying for a mortgage, getting a small business loan, or refinancing a personal credit card — exist a network of trust and credit rela...
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Big data’s roots are in the hyperscalers. As a result, most tooling we use for analytics today has been built around a scale-out approach where performance is sacrificed for the ability to handle enormous amounts of data...
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VisiCalc, the first computer-based spreadsheet, was launched in 1979. For the first time, this brought data analysis and computing together, in a way thousands of times more powerful than pen and paper. While VisiCalc is...
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Today’s digital workplace moves faster than at any point in history. We can communicate and collaborate in real-time—and around the world—across text, voice, video, and documents. We can share massive files with a URL an...
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Historically, wealth managers offered consumers a choice: either put their money on autopilot (through an offering like Vanguard’s low-fee ETFs) or — if wealthy enough — be actively managed by an advisor at somewhere lik...
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Freight is quite literally one of the backbones of the U.S. economy. Every year, shippers spend $800 billion dollars moving goods across the country, and as everyone learned firsthand over the past two years, one small h...
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As we write in our piece It’s All About The Money (Movement), moving money internationally is an opaque, fee-intensive process that requires two things: actually “moving” the money and leveraging onboarding and complianc...