Seth Hain, SVP of R&D at Epic, joins a16z Bio + Health general partner Julie Yoo to explore technology in healthcare. Reflecting on over two decades of industry shifts, Seth shares how Epic has transitioned from enab...

What happens when AI doesn’t just generate content, but embodies it? I tested over 20 AI avatar products to understand what’s working and what's next.

Building your own GPU server—like the one described here—means no API calls to external services, no data leakage, and no usage throttles.

By Colin Campbell and Jonathan Lai

When people think about startups working with the government, the phrase “black box” often comes up. But what if that box is finally being pried open?

Elliot Cohen, cofounder of PillPack, joins Julie Yoo, a16z Bio + Health general partner. Together, they discuss Elliot's experience designing and building a consumer-first pharmacy alongside TJ Parker.

At a16z'a fourth annual Connect/Fintech event, discussions spanned what's working in AI, operational lessons on how to scale faster, and the future of banking charters.

We’re investing up to $1M in pre-seed/seed startups in tech, entertainment, and AI. Apply by May 11 → sr.a16z.com

Cher's digital closet was just the beginning. Online shopping is becoming intelligent, predictive, and visually intuitive.

Convex cofounder and Chief Scientist Sujay Jayakar and a16z General Partner Martin Casado discuss the real challenges of autonomous software development and why robust evals — and guardrails like type safety — matter more than ever.

Bundling your products can deepen your moat — or shrink your margins. Use these gut-checks before you pull the lever.

This month, a16z’s Consumer team released the fourth edition of the GenAI 100 — a data-driven ranking of the top 50 AI-first web products and mobile apps, based on unique monthly visits and active users.

Resend's Zeno Rocha and a16z's Yoko Li discuss how AI agents and MCP are reshaping the developer experience for email creation and programming overall.

Younger founders often lack the deep networks important for distribution and earned insights around high-value problems that older founders have. AI changes that.

The global race for AI leadership is no longer just about companies—it’s about nations. AI isn’t just computing infrastructure; it’s cultural infrastructure, economic strategy, and national security all rolled into one.

We explore what MCP is, how it changes the way AI interacts with tools, what developers are already building, and the challenges that still need solving. 

AI voice technology has been around for years — think Siri or Alexa — but the magic has been missing. That’s changing, and quickly!

The US government should invest in AI talent and infrastructure to ensure that Little Tech has the ability to compete and thrive.

This week, a16z shared our recommendations with the White House Office of Science and Technology Policy (OSTP) for how the United States can implement a competitiveness agenda that will enable it to continue to lead the world in AI development.

Sesame's Ankit Kumar and a16z's Anjney Midha do a deep dive into the research and engineering behind Sesame's cutting-edge AI model for conversations.

For startups, working with the Department of Defense (DoD) can feel like stepping into a fortress of bureaucracy — procurement is slow, compliance is daunting, and knowing who actually makes buying decisions is like navi...

We back founders pushing the limits of tech and entertainment.

These 50 companies aren’t just strengthening America’s ability to deter conflict, they’re re-industrializing America in the process.

For over a century, the United States has been the birthplace of world-changing innovation – from the Wright brothers’ first flight to the invention of the transistor, the moon landing, and the birth of the internet. But...

In this episode, Slingshot AI cofounders Daniel Cahn and Neil Parikh join a16z Bio + Health general partner Julie Yoo to explore how their mission to transform mental health care with AI took shape. Drawing from their un...

We unpacked the unconventional tactics in Deel's playbook to help guide the business strategy and culture of other startups.

AI is reshaping web development. At the center is agent experience (AX), a new paradigm where AI agents open new capabilities in web design and experience.

Henry Ward, cofounder and CEO of Carta, has spent over a decade scaling his company from an early-stage startup to a 2,000-person industry leader. In this a16z Speedrun conversation with Games partner Josh Lu, Henry shar...

Which AI apps are people actively using? What’s actually making money, beyond being popular? We analyzed the data.

a16z partners Guido Appenzeller and Marco Mascorro demystify how DeepSeek works and explain what the era of reasoning models means for AI.

We recently kicked off the latest a16z Talent x Opportunity initiative cohort in San Francisco with founders from five promising startups building software-enabled companies across fashion, gaming, media, and music.

In this episode of AI + a16z, a trio of security experts join a16z partner Joel de la Garza to discuss the security implications of the DeepSeek reasoning model that made waves recently. It's three separate discussions,...

For voice agents in finance to become successful, they will need to navigate a number of industry-specific nuances.

Being a creator in 2025 is tough—but building for creators is even harder. Perhaps no one understands this conundrum better than Scott Belsky. As the founder of Behance, a longtime executive at Adobe, and an advisor to c...

Dr. Muthu Alagappan, MD, founder and CEO of Counsel Health, joins Julie Yoo, a16z Bio + Health general partner, to dive deep into the company's vision for revolutionizing healthcare through AI-powered asynchronous care....

Harvey's Aatish Nayak discusses building AI products for enterprises, including the legal profession, and how to address areas like UX, trust, and pricing.

Will the next era of the internet be shaped by a handful of players—or transformed into an open ecosystem?

The right investment in RevOps separate great GTM engines from good-enough GTM engines. Here's a cheatsheet for investing in RevOps as you scale.

Hebbia's George Sivulka discusses the potential for reasoning models and AI agents to supercharge the global economy.

No company loves their enterprise resource planning system (ERP). So why are ERPs the way they are, and why is now the right time for them to change?

The business process outsourcing (BPO) market is massive, and we believe there is a clear opportunity with AI to productize and unbundle the BPO.

What products are builders using to make websites and web apps with AI? A deep dive into how these products work, their limitations, and the features on the horizon. 

Ankit Jain, CEO and cofounder of Infinitus Systems, Inc, joins Julie Yoo, a16z Bio + Health general partner, to discuss Infinitus's work in solving one of healthcare's most pressing challenges: workforce shortages. Lever...

Critical materials like copper, lithium, and gallium have been mined for decades, but their role in core technologies, geopolitics, and the energy transition have come to a height in recent years.

Fivetran cofounder and CEO George Fraser and a16z partner Guido Appenzeller discuss how LLMs fit into the data management picture within large enterprises.

Two words have caught the Internet by storm. DeepSeek.

Machine learning methods applied to physics will speed up simulation times by orders of magnitude and revolutionize the engineering development process.

Does your business complexity justify changing senior finance leadership? Compare your current leader to five dimensions that define a truly gifted CFO.

a16z's Marc Andrusko chats with Mastercard’s Chief AI and Data Officer Greg Ulrich about their long history of using AI, integrating generative AI into fraud detection, and the best advice he’s ever gotten.

With state legislative sessions now in full swing and a new Congress and Presidential administration beginning in Washington, it is important to consider the respective roles that state and federal governments might play in regulating AI.

This week, a16z cofounder Ben Horowitz had a rare and invaluable conversation with Dr. Clarence B. Jones, a pivotal figure in American history.

DeepSeek, China’s AI breakthrough, has exposed the U.S.'s policy failures. And not a day too soon.

In the January 2025 Fintech newsletter, we break down the rise of vertical AI in accounting, big ideas for 2025 in fintech, and market intel.

Voice is one of the most powerful unlocks for AI application companies. As models improve, AI voice will become the wedge, not the product.

Anduril reimagined how startups can build software and hardware for the defense sector. Now, they're using AI to reimagine modern warfare.

Alexander Saint-Amand, cofounder and CEO of Topography, reflects on his journey from leading Gerson Lehrman Group (GLG), a pioneer in expert networks, to tackling systemic barriers in clinical trials at his current compa...

To ensure that AI can achieve its potential and that Little Tech can compete with larger platforms, policy should focus on how AI is used, not how AI is built.

Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shif...

In the “Maslow's hierarchy” of the healthcare industry’s needs, the infrastructure layer is the foundational workhorse of the system. Healthtech infrastructure refers to the utilities and systems-of-record that underpin all of the core operational transactions, financial transactions, data exchange, and interoperability actions that occur across the healthcare system everyday.

Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why i...