The idea of ‘designing biology’ — once science fiction — has over the last 20 years become just… science. In this episode, a16z bio general partner Vijay Pande with Hanne Tidnam talk all about the field of synthetic biology with James J. Collins, professor of bioengineering at MIT. Collins, whose work in synthetic biology and systems biology pioneered the field, has also launched a number of companies and received numerous awards and honors (including a MacArthur “Genius” Award, an NIH Director’s Pioneer Award, and Sanofi-Institut Pasteur Award).
This wide-ranging conversation about the birth of synthetic biology covers everything from the founding story of the discipline to what “engineering and designing” biology really looks like in action — when instead of engineering electrons, you are engineering toggle switches for genes — to the disciplinary differences (and synergies) between how biologists and engineers see the world. What are the engineering and design principles, techniques, approaches that work best when applied to science? How does building a company in this new space look different, in terms of platforms and products? And how is this new field changing education in science, all the way down to kits that allow you to play with the machinery of a cell… at home… and even in middle school?
James J. Collins
Vijay Pande is the founding General Partner of a16z Bio + Health, focused on the cross-section of biology and computer science.
Hanne Winarsky is the Head of Writer Acquisition & Development at Substack.
The a16z Podcast discusses the most important ideas within technology with the people building it. Each episode aims to put listeners ahead of the curve, covering topics like AI, energy, genomics, space, and more.