a16z Podcast

a16z Podcast: Move Fast But Don’t Break Things (When It Comes to Computational Biology)

Jeffrey Kindler, Andrew Radin, and Vijay Pande

Posted June 13, 2016

The mindset of “move fast and break things”, while great for code, isn’t exactly great for the human body. So adding computation to biology — especially in the slow-moving pharmaceutical industry, where drug approval can take years — brings with it both opportunities (like drastically faster discovery and assessment) and challenges (the need for hard evidence, not just soft-ware). But there’s more: We don’t want just better outcomes for healthcare. We want better outcomes at a cheaper price. 

And that’s where machine learning comes in. The benefits of such computation — i.e., software — can provide a powerful, frictionless, and far more cost-effective tool for biopharmaceutical research … but it requires data. So who provides that data? Is it the pharmaceutical companies, or the payers (insurance)? How are organizations incented to overcome intellectual property silos in sharing their data? Especially since it was only relatively recently, Jeff Kindler (the former CEO of the world’s largest pharmaceutical company, Pfizer) reminds us in this episode of the a16z Podcast, that the FDA even allowed data to be put in computers vs. on paper.

But there’s a reason the self-driving car was pushed out of the software and not the auto industry, argues TwoXAR co-founder and CEO Andrew Radin — and it has to do with the unique nature of the developer’s mindset applied to novel problems. The deterministic nature of Moore’s Law — it’s not a matter of if, but when — plays a role too, observes a16z bio fund general partner Vijay Pande. There are things that big data and simulations will be able to accomplish that a hundred lab experiments on animals can’t. Still, the two mindsets will have to merge, so we can move fast … but without compromising quality, safety, and reliability. That’s the big difference between computer science and biology after all.

image: mattza/ Flickr