Investment News

GCTx is flipping the entire iPSC differentiation paradigm on its head. Rather than manually iterating through a limited set of differentiation protocols, the Human TFome technology platform instead deploys large-scale combinatorial screening to discover new hypotheses and new protocols that are as-yet unknown to even the best biologists.

Fei-Fei Li and are team of experts at World Labs are building a spatial intelligence model that can generate 3D worlds that users can interact with.

Mintlify lets companies publish quality software documentation that aligns with their brands, including guides, API reference, and examples.

Pylon provides a single view of customer issues, wherever they are happening — Slack, Teams, chat widget, ticket forms, or emails.

Cursor is a fork of VS Code that’s heavily customized for AI-assisted programming, with loads of features designed to integrate AI into developer workflows.

We're excited to announce our investment in Black Forest Labs (BFL), which is building the world’s best open visual models for developers.

Daylight is building a decentralized protocol to fund and coordinate distributed energy resources.

a16z is proud to lead Saronic’s Series B and continue supporting founder and CEO Dino Mavrookas and his team of engineers, veterans, and operators.

We are entering the new SaaS era, moving from Software-as-a-Service to Service-as-a-Software.

Pharma represents one of the biggest industries in the world. The top 10 pharma companies account for over $3.4T in aggregate market cap, and last year, the US alone spent more than $700B on pharmaceuticals and prescript...

We’re excited to share that we’re investing in k-ID - the best-in-class compliance engine for online safety and privacy management.

Recently, we invested in Function Health, a company that embodies the vision and excitement we had when writing those theses. The one piece we underestimated is the current state of latent demand among consumers for a new approach to healthcare and longevity.

This medical home is exactly what knownwell is building – and scaling. Through a hybrid virtual and in-person care model, knownwell offers both primary care as well as longitudinal specialty care, inclusive of weight management, diabetes care, medication (and side effect) management, multi-disciplinary nutritional counseling, and behavioral health services.

a16z is excited to invest in Decagon, an AI agent that automates customer support for a business, and to have led their seed round.

Talkiatry addresses the acute end of the behavioral health market—psychiatric care—by offering virtual treatment covered by patients’ insurance.

There is perhaps nowhere more exciting or impactful to build such tools than in healthcare—where progress is often so constrained by human expertise. Valar Labs is taking on exactly this challenge, and bringing AI into the toolbox for better cancer care.

We're thrilled to lead the $5M seed round for Yellow, a company focused on revolutionizing 3D character creation through generative AI.

The opportunity to build the next iconic cybersecurity platform has arrived: Wiz, a global leader in cloud-native security.

Tennr understands unstructured inputs, applying AI reasoning and decision-making to perform complex end-to-end workflows.

We’re excited to partner with the Espresso team to help bring to life a more seamless and interoperable future for Ethereum.

We’re excited to announce A16Z GAMES' investment in Kaedim, a new type of co-development platform providing AI-powered art outsourcing.

The release of the latest Ideogram.ai model is a massive step forward for image models. We're excited to lead their Series A.

It's a pleasure to announce that we're leading EigenLayer's Series B. We're excited to partner with founder Sreeram Kannan and the whole team on building a platform that unlocks a new dimension of open innovation on top of Ethereum.

Tigris has built a globally available S3-compatible distributed object-storage service that makes the application developer’s job as simple as possible.

Upstash powers caching and messaging for tens of thousands of production applications across four different products, including many AI applications.

As students of financial markets, we’re keenly interested in moments of inflection which alter market structure, spawn dominant new institutions, and catalyze the growth of new asset classes. Historically, these shifts h...

Doppel is building a next-generation approach for detecting and removing fraudulent accounts and phishing attacks across various channels.

Over the past decade, data infrastructure across industries has been modernized by many disruptors like Databricks, Fivetran, et al. The modern data stack has made it much easier for companies to ingest, store, query, an...

What will it take for AI to go mainstream with consumers? Effective model aggregation, a better UI, and a powerful platform for creators. Enter Poe.

Luma AI is building fast, high-quality, and deployable foundation models that let anyone create interactive 3D assets based on text prompts.

Distributional is building a platform for robust and repeatable testing of AI and machine learning models so teams can push to prod confidently.

Tome is launching with over $200 million to advance its PGI platform to focus on in vivo and ex vivo applications, with support from a16z Bio + Health, ARCH, GV, Longwood, Polaris and other leading investors. First up on Tome’s in vivo surgical slate: monogenic diseases of the liver. On the ex vivo cell engineering front, Tome is using PGI to rewire cells to cure common, chronic diseases—an area of great promise—with an initial focus on B-cell driven autoimmune diseases.

Mistral is at the center of the open source AI developer community. This is the most promising path to achieve robust and trusted AI systems.

Air Space Intelligence is a modern aerospace company addressing the software crisis in aerospace in both the enterprise and government sectors.

While most small molecule drugs bind and inhibit the disease-causing activity of their (typically intracellular) protein targets, Gate Bio instead attacks harmful extracellular proteins by eliminating them at their very root: right where they are produced and secreted from the cell.

911 call centers – also known as public safety answering points (PSAPs) – are one of the most actively used public-safety infrastructure systems in the United States, fielding an estimated 240 million calls per year. Tha...

Led by CEO and Founder Ben Leventhal, Blackbird seeks to reward and delight consumers with elevated dining experiences, powered and personalized by web3.

We’re leading a Seed investment in Proof of Play, an on-chain game studio and tech company that’s committed to building a future with composability, interoperability, and permanence at the core of gameplay.

TipTop creates tools that reduce the consumer code of owning products. They offer customers a guaranteed buyback price at the time of purchase, so they only pay for the product while they need it.

a16z will lead the Series A of Moment, a new company building infrastructure that abstracts away the complexities of embedding fixed income investments in any application.

Socket monitors open source packages for the most important security issues, covering the spectrum of risk across the software supply chain.

Apex’s flagship Aries platform satellite bus is being manufactured for scale, targeting both commercial and defense companies where speed is critical.

ElevenLabs is on a mission to give every program a voice through its proprietary speech synthesis, voice design, and cloning technology

As we have seen the Pomelo team build out their virtual clinic, care model, and software platform, they are dedicated to a few key principles which we believe are absolutely critical to building a scalable company in this space.

The very nature of generative AI—conversational, scalable, accessible to non-technical users—has the potential to solve the shortcomings of previous generations of rules-based chatbots and other such products in making these concepts a reality.

We’re leading a $100 million Series B round in vector database provider Pinecone, to support its vision of becoming the memory layer for AI applications.

Most people don’t know that nuclear energy — a clean, carbon-free energy source — accounts for 20% of electricity in the United States and over half of its carbon-free electricity. However, while large nuclear reactors a...

Character AI is a platform, based on a proprietary LLM, for creating and chatting with different AI characters. We're leading their Series A!

Years before the first blockchain was created, the sci-fi space MMO EVE Online proved out many of the core principles that define web3 today. This is why we are excited to be partnering with CCP on a new project set in t...

Understanding what’s in an image — one of the simplest cognitive tasks for most humans — is a stubbornly difficult problem for artificial intelligence systems to solve.

The contractor payroll market is massive. Roughly one-third of U.S. workers have performed freelance work in the last year, and $1.4 trillion is paid out to contract workers annually. In many ways, contractors are the ba...

There is a moment of wonder in every great game that makes you sit back, take a breath, and really appreciate what it is that you’re experiencing: stepping out into the world of Zelda, overcoming Margit for the first tim...

Every so often, we meet founders with unusually strong conviction about solving systems problems. They’ve often lived through the pain of bad software, diagnosed the cause of their suffering, and made it their mission to...

It’s very rare to see a new building block emerge in computing. If aliens landed on earth and decompiled our software, every app would look roughly the same: some combination of networking, storage, and compute. The way...

Every student can learn, just not on the same day, or the same way. – George Evans

We are thrilled to announce that a16z Games has led the Series Seed investment in Snapser, a games backend technology company poised to become the de facto platform for games studios.

In recent years, we’ve seen a renaissance in productivity software. To make knowledge work seamless, internal teams have largely moved off of “hard files,” toward real-time workspaces with commenting, collaboration, and...

Debt is daunting—its labyrinth of complex rules, opaque governing bodies, and unique vernacular makes it difficult for the average consumer to understand. Concepts like credit scores, APRs, retroactive interest, and coll...

We are thrilled to announce that a16z led the Series A investment in Voldex, a game studio that acquires, improves, and builds games on the massive user-generated content (UGC) platforms, Roblox and Minecraft.

Cyber incidents have reached a crisis level over the past decade. In 2021, the U.S. saw 1,862 data compromises, affecting nearly 300 million people (a nearly 100% increase from five years ago). Cybersecurity practitioner...

Within every era of technology, the most talented entrepreneurs have taken unsolved problems and open questions and turned them into businesses.

We’re thrilled to announce that Andreessen Horowitz is leading the seed investment in Seidr AB who are building the next generation of midcore cross-play games. Based in Stockholm, a hotbed of games innovation, Seidr’s f...

Behind many of life’s most important financial transactions — be it buying a house, applying for a mortgage, getting a small business loan, or refinancing a personal credit card — exist a network of trust and credit rela...

Big data’s roots are in the hyperscalers. As a result, most tooling we use for analytics today has been built around a scale-out approach where performance is sacrificed for the ability to handle enormous amounts of data...

VisiCalc, the first computer-based spreadsheet, was launched in 1979. For the first time, this brought data analysis and computing together, in a way thousands of times more powerful than pen and paper. While VisiCalc is...

Today’s digital workplace moves faster than at any point in history. We can communicate and collaborate in real-time—and around the world—across text, voice, video, and documents. We can share massive files with a URL an...

Historically, wealth managers offered consumers a choice: either put their money on autopilot (through an offering like Vanguard’s low-fee ETFs) or — if wealthy enough — be actively managed by an advisor at somewhere lik...

Freight is quite literally one of the backbones of the U.S. economy. Every year, shippers spend $800 billion dollars moving goods across the country, and as everyone learned firsthand over the past two years, one small h...

As we write in our piece It’s All About The Money (Movement), moving money internationally is an opaque, fee-intensive process that requires two things: actually “moving” the money and leveraging onboarding and complianc...

If you’ve run a high-growth company, you know that office space decisions are a nightmare. You are forced to anchor your growth assumption in cement--literally--for a typical lease term of seven years.

Interoperability has long been a key guiding principle of the Metaverse - a vision that we can bring our digital identity and assets with us as we travel between virtual worlds.

Our nation has a housing crisis.

HIV ravaged entire communities before antiretroviral cocktail therapies helped turn the tide. Cocktail therapies combine multiple drugs: Some hit parts of the replication machinery the virus uses to make copies of itself...

We’re very excited to announce that we’re leading the series B for Fly.io. Fly is one of the fastest-growing core infrastructure companies we have ever seen. And it’s worth understanding why.

Vicinitas (noun), Latin

We’re excited to announce that a16z is leading the Series A for Nash, an API-based platform for last-mile delivery.

“Maps are the most condensed humanized spaces of all...They make the landscape fit indoors, make us masters of sights we can't see and spaces we can't cover.” -- Robert Harbison, Professor of Architecture

Buying traditional insurance is a no-brainer if you want to protect assets of value—be it your life, your home, or your business. If you own, say, a building, chances are you’ll want to minimize your risk against fires,...

One of the greatest challenges the world faces today is how to sustainably feed our ever-growing global population without compromising the environment or human health. Compounding this challenge are rapidly rising level...

Many of the most popular, genre-defining games trace their heritage to what are called “mods”—player-made modifications to existing games. The mods are built from developer tools within the game so that players can creat...

When I was 22, I spent several months working in the field in South Africa. I was there as a part of a research project funded by the National Science Foundation, whose aim was to better understand the role of that regio...

From Shakespeare to the Beatles, and Star Wars to Fortnite, every generation has a set of entertainment properties that define its culture and shared universe of stories. As we look to the coming decade, we believe the n...