Two words have caught the Internet by storm. DeepSeek.

Machine learning methods applied to physics will speed up simulation times by orders of magnitude and revolutionize the engineering development process.

Does your business complexity justify changing senior finance leadership? Compare your current leader to five dimensions that define a truly gifted CFO.

a16z's Marc Andrusko chats with Mastercard’s Chief AI and Data Officer Greg Ulrich about their long history of using AI, integrating generative AI into fraud detection, and the best advice he’s ever gotten.

With state legislative sessions now in full swing and a new Congress and Presidential administration beginning in Washington, it is important to consider the respective roles that state and federal governments might play in regulating AI.

This week, a16z cofounder Ben Horowitz had a rare and invaluable conversation with Dr. Clarence B. Jones, a pivotal figure in American history.

DeepSeek, China’s AI breakthrough, has exposed the U.S.'s policy failures. And not a day too soon.

In the January 2025 Fintech newsletter, we break down the rise of vertical AI in accounting, big ideas for 2025 in fintech, and market intel.

Voice is one of the most powerful unlocks for AI application companies. As models improve, AI voice will become the wedge, not the product.

Anduril reimagined how startups can build software and hardware for the defense sector. Now, they're using AI to reimagine modern warfare.

Alexander Saint-Amand, cofounder and CEO of Topography, reflects on his journey from leading Gerson Lehrman Group (GLG), a pioneer in expert networks, to tackling systemic barriers in clinical trials at his current compa...

To ensure that AI can achieve its potential and that Little Tech can compete with larger platforms, policy should focus on how AI is used, not how AI is built.

Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shif...

In the “Maslow's hierarchy” of the healthcare industry’s needs, the infrastructure layer is the foundational workhorse of the system. Healthtech infrastructure refers to the utilities and systems-of-record that underpin all of the core operational transactions, financial transactions, data exchange, and interoperability actions that occur across the healthcare system everyday.

Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why i...

Andreessen Horowitz (a16z) Bio + Health today announced a newly formed, first-of-its-kind venture capital fund to fuel broader innovation in human health, in partnership with Eli Lilly and Company (“Lilly”). The Biotech Ecosystem Venture Fund (“Fund”) seeks to drive transformative progress in healthcare by investing in therapeutic platforms and cutting-edge technology companies that can bring new medicines and disease treatments to improve patients’ lives.

Rajaie Batniji, MD, PhD, Afia Asamoah, JD, and Sanjay Basu, MD, PhD, cofounders of Waymark, join Vineeta Agarwala, MD, PhD, a16z Bio + Health general partner, to discuss their transformative approach to Medicaid care delivery.

Martin Casado and Alan Nichol discuss how to build reliable AI agents and chatbots — from early NLP approaches to integrating LLMs with business logic.

Hippocratic AI cofounder and CEO Munjal Shah joins a16z Bio + Health general partner Julie Yoo to explore the incredible potential of generative AI in transforming healthcare delivery.

Email, a technology from 1971, is powering one of today’s most disruptive media platforms.

Jeff Margolis, founder of TriZetto, joins Julie Yoo, a16z Bio + Health general partner, to share the journey of building an iconic company in healthcare infrastructure. From the early days of managed care to creating a t...

As we prepare to step into 2025, the possibilities for applied AI are reshaping industries in profound ways.

A 2024 highlight reel from the AI + a16z podcast, featuring insights, advice, and experiences from building AI companies.

The AI race is on, and 2025 could be its most transformative year yet.

Reviewing the top posts and themes from a16z crypto in 2024. Plus, stablecoins and crypto guides.

As 2025 begins, industries are evolving at unprecedented speed: robots are revolutionizing manufacturing, terabytes of earth observation data are driving new possibilities, and gaming technology is transforming how we de...

Jack Henry CTO Ben Metz shares how banks’ historical tech infrastructure and regulatory obstacles have stymied innovation—and how Jack Henry is helping them overcome these challenges.

In the December 2024 Enterprise Newsletter, we discuss how AI is now driving the beginning of yet another and possibly more dramatic pricing shift.

Decagon CEO Jesse Zhang and a16z's Kimberly Tan discuss how LLMs are reshaping customer support and how AI agents enable a disruptive pricing model.

The a16z consumer team tapped a grab bag of fellow early-adopters and AI enthusiasts to share their favorite products from a weird and wonderful year.

There actually is a reasonable policy position on AI regulation: focus on marginal risk and apply our regulatory energy there.

In this episode of "My First 16," a16z Partner Seema Amble talks with MongoDB and Viam co-founder Eliot Horowitz about building sustainable open source software tools.

Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero?

a16z Partner Seema Amble connects with Zapier co-founder Wade Foster about the company’s founding and GTM success utilizing a product-led growth (PLG) strategy.

Matt Wilsey, cofounder and CEO of Grace Science, joins Jorge Conde, Bio + Health general partner, to share the profound personal story of his daughter Grace's diagnosis with NGLY1 deficiency and how it catalyzed his journey to founding a biotech startup aimed at developing a cure for his daughter’s condition.

World models represent a credible promise for leveling the playing field, enabling “little robotics” to innovate and compete more effectively. 

In this episode of "My First Sixteen," a16z's Seema Amble chats with Gusto cofounder Tomer London about establishing product-market fit and product discovery.

An external "AI brain." Big swings in biopharma. Infinite games. A nuclear resurgence. "Faceless" creators. Google search challengers. Battlefield AI. We asked 50 a16z partners to preview one big idea that will spur innovation in 2025.

In this post, we will look at how AI will open new markets previously deemed too “small” to support a large vertical SaaS company.

Carolyn Bertozzi, PhD, Director of Sarafan Stanford ChEM-H and professor at Stanford University, joins Jorge Conde, general partner at a16z Bio + Health.

Sales is evolving. AI-native systems are replacing traditional CRM tools, capturing unstructured insights from emails, Slack, surveys, and more in real time. These systems automate early-stage tasks like prospecting and...

The Cultural Leadership Fund (CLF) remains focused on bringing African Americans into tech at the earliest stages of innovation. Our 2024 nonprofit partners add unique strengths and fresh perspectives to our growing network. We’re excited to collaborate to increase Black participation across the tech ecosystem.

In this special episode, Marc and Ben sit down with Chief Mike Gennaro and Sheriff Kevin McMahill of the Las Vegas Metro Police Department (LVMPD) to discuss how their organization is using technology to become the safes...

What if the biggest challenge of our time isn’t living longer, but living better?

Replicate CEO Ben Firshman and a16z partner Matt Bornstein discuss the art of building productss — from PaaS to AI — that appeal to software developers.

As AI turns labor into software, the opportunity to productize external professional services has become a hot topic. However, we believe there is also substantial opportunity in productizing internal work within organizations.

In this special post-election episode, Marc and Ben reflect on Trump's dramatic political victory and its potential impact for startups—particularly in AI, crypto, and defense.

For LLM of equivalent performance, the inference cost is decreasing by 10x every year. What cost $60/million tokens in 2021 costs $.06/million tokens today.

In this episode, a16z partners Jorge Conde and Jay Rughani sit down with Sajith Wickramasekara, CEO and cofounder of Benchling, to unpack the evolution of Benchling from idea to transformative software platform.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace.

Marc and Ben dive into the latest AI policy updates, emphasizing the need for informed debate on AI’s risks and benefits, and the policies needed for AI startups to thrive and collaborate. This conversation follows a16z'...

Brian Roberts is joining Andreessen Horowitz as a General Partner, where he will work across the American Dynamism and AI Apps funds.

Andy McCall is joining Andreessen Horowitz as a General Partner. He will work across the American Dynamism and AI Apps funds.

2024 has been a milestone year for autonomous tech.

Pedro Domingos joins Martin Casado to discuss the state of AI, whether we're really on a path toward AGI, and the value of expressing unpopular opinions.

a16z and Microsoft share policy ideas for AI startups so they can thrive, collaborate, and compete.

Marc and Ben explore the intensifying competition between the U.S. and China in artificial intelligence and robotics, assessing the U.S.'s strengths in software development while raising concerns about China’s growing do...