Matt Wilsey, cofounder and CEO of Grace Science, joins Jorge Conde, Bio + Health general partner, to share the profound personal story of his daughter Grace's diagnosis with NGLY1 deficiency and how it catalyzed his journey to founding a biotech startup aimed at developing a cure for his daughter’s condition.

World models represent a credible promise for leveling the playing field, enabling “little robotics” to innovate and compete more effectively. 

In this episode of "My First Sixteen," a16z's Seema Amble chats with Gusto cofounder Tomer London about establishing product-market fit and product discovery.

An external "AI brain." Big swings in biopharma. Infinite games. A nuclear resurgence. "Faceless" creators. Google search challengers. Battlefield AI. We asked 50 a16z partners to preview one big idea that will spur innovation in 2025.

In this post, we will look at how AI will open new markets previously deemed too “small” to support a large vertical SaaS company.

Carolyn Bertozzi, PhD, Director of Sarafan Stanford ChEM-H and professor at Stanford University, joins Jorge Conde, general partner at a16z Bio + Health.

Sales is evolving. AI-native systems are replacing traditional CRM tools, capturing unstructured insights from emails, Slack, surveys, and more in real time. These systems automate early-stage tasks like prospecting and...

The Cultural Leadership Fund (CLF) remains focused on bringing African Americans into tech at the earliest stages of innovation. Our 2024 nonprofit partners add unique strengths and fresh perspectives to our growing network. We’re excited to collaborate to increase Black participation across the tech ecosystem.

In this special episode, Marc and Ben sit down with Chief Mike Gennaro and Sheriff Kevin McMahill of the Las Vegas Metro Police Department (LVMPD) to discuss how their organization is using technology to become the safes...

What if the biggest challenge of our time isn’t living longer, but living better?

Replicate CEO Ben Firshman and a16z partner Matt Bornstein discuss the art of building productss — from PaaS to AI — that appeal to software developers.

As AI turns labor into software, the opportunity to productize external professional services has become a hot topic. However, we believe there is also substantial opportunity in productizing internal work within organizations.

In this special post-election episode, Marc and Ben reflect on Trump's dramatic political victory and its potential impact for startups—particularly in AI, crypto, and defense.

For LLM of equivalent performance, the inference cost is decreasing by 10x every year. What cost $60/million tokens in 2021 costs $.06/million tokens today.

In this episode, a16z partners Jorge Conde and Jay Rughani sit down with Sajith Wickramasekara, CEO and cofounder of Benchling, to unpack the evolution of Benchling from idea to transformative software platform.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace.

Marc and Ben dive into the latest AI policy updates, emphasizing the need for informed debate on AI’s risks and benefits, and the policies needed for AI startups to thrive and collaborate. This conversation follows a16z'...

Brian Roberts is joining Andreessen Horowitz as a General Partner, where he will work across the American Dynamism and AI Apps funds.

Andy McCall is joining Andreessen Horowitz as a General Partner. He will work across the American Dynamism and AI Apps funds.

2024 has been a milestone year for autonomous tech.

Pedro Domingos joins Martin Casado to discuss the state of AI, whether we're really on a path toward AGI, and the value of expressing unpopular opinions.

a16z and Microsoft share policy ideas for AI startups so they can thrive, collaborate, and compete.

Marc and Ben explore the intensifying competition between the U.S. and China in artificial intelligence and robotics, assessing the U.S.'s strengths in software development while raising concerns about China’s growing do...

a16z cofounders Marc Andreessen and Ben Horowitz explore an unusual intersection of AI and crypto: the sudden rise of a bot-beloved memecoin.

a16z General Partner Anjney Midha discusses the Nobel Prizes awarded to AI researchers, and how work dating back decades led to today's AI-powered world.

What does Rich Sutton’s "Bitter Lesson" reveal about the decisions Tesla is making in its pursuit of autonomy?

We’re excited to welcome Teach.Empower.Achieve., Unlocked Labs, and VetsinTech to the TxO community as our 2024 grantees!

Oxygen is an a16z program that helps AI startup founders navigate their compute challenges and access the GPUs and other resources they require.

Marc and Ben explore the intersection of AI and crypto, highlighting the rise of Truth Terminal, an autonomous chatbot developed by AI researcher Andy Ayrey. With its own X account, Truth Terminal generates original and...

The VP of Apple Pay and Apple Wallet discusses the challenges she confronted pushing Apple Pay into the mainstream, new Apple verticals on the horizon, and her advice for early entrepreneurs.

Chris Ellis, CEO and Adam Stevenson, president, both cofounders of Thatch, join Julie Yoo and Jay Rughani of a16z Bio + Health.

Behind the scenes of our 2024 State of Crypto Report — stablecoins, AI, builder energy, U.S. election, more — on the web3 with a16z podcast.

The 2024 guide to this year's State of Crypto report — from all-time highs in crypto activity to key applications in AI, stablecoins, and more.

LLMs can now enable experiences that capture data at the point of creation in ways that were impossible for traditional software.

AMD CEO Lisa Su lays out her vision for the evolution of compute within the AI ecosystem.

How to estimate the number of monthly active crypto users given that common metrics like active addresses are so easily gamed.

Explore the data behind all-time highs in crypto activity, key advances in blockchain technologies, and next-generation applications in gaming, AI, and more.

Every day, millions of SMBs waste countless hours synthesizing waves of unstructured information and entering data into systems of record. We call this the “messy inbox problem.”

David's mental models for growth-stage investing, what it really takes to go public, where AI is today and where it’s headed, and more.

Jonathan Lim, chairman and CEO of Erasca, joins Jorge Conde, general partner at a16z. In a recent conversation, Lim shared valuable insights about his transition to the biotech world, his leadership experiences, and the lessons he's learned while founding and guiding organizations through high-stakes decision making.

How policymakers can implement measures that will help catching bad actors and reign in illicit financial activity in crypto

Highlights from the Science of Blockchain Conference, a premier conference bringing together researchers and builders, in NYC August 7-9, 2024

Las Vegas Metro Police improved public safety with $6.3M in state-of-the-art tech from Skydio and Flock Safety, enhancing intelligence and awareness.

Deepfakes—AI-generated fake videos and voices—have become a widespread concern across politics, social media, and more. As they become easier to create, the threat grows. But so do the tools to detect them.

Today characters are owned by corporations, but NFTs and DAOs enable communities to bring new characters and culture to the world.

In this talk Ron Lavi describes “VCG contracts,” a type of “contractible contracts” – contracts where the payment of a principal to an agent can also be conditioned on details specified in contracts that other principals submit.

Deepak Maram (Mysten Labs) introduces zkLogin, a user-friendly innovation for cryptocurrency wallets.

While tech platforms have helped us discover and connect with more artists than ever — including more independent artists — a few mainstream artists continue to dominate platforms. It’s a structural problem in the entertainment industry, and also involves the way many tech platforms operate today: Creators need power, power comes from control, and control comes from ownership.

I’ve been using ChatGPT like a daily journal to translate my innermost thoughts and feelings into a readily understandable format. I've been blown away by the results.

Voices Onchain highlights creators who have turned to blockchain technology to unlock new creative possibilities, build deeper connections with fans, and discover more ways to monetize their work.

Last week was another big week in technology.

Vijay Pande, general partner, and Daisy Wolf, investing partner, join host Steph Smith on this crossover episode of the a16z podcast.

Yehuda Lindell introduces the notion of an exponent-VRF, or eVRF, a VRF that provides a generator of some finite cyclic group

Abhi Shelat identifies a specific rewriting of the ECDSA signing equation and a method to compute and verify it.

In 1995, just 2% of couples met online. Today, that number has surged to over 50%, making online dating the top way couples connect.

In this month's fintech newsletter, we look at how AI is driving a new beginning for fintech. Plus, when fintechs look more like banks, what does it mean for valuations?

Marta Bralic Kerns, founder and CEO of Pomelo Care, joins Will Shrank, MD, a16z Bio + Health venture partner. Together, they talk about the innovator’s dilemma with building in the Medicaid space

Bowen Peng and Jeffrey Quesnelle of Nous Research discuss their mission to accelerate open source AI research, including with a new project called DisTrO.

It feels like software is shrinking while everyone is scrambling to buy generative AI. What’s changed, and how can you get a leg up?

Blackstone's CTO describes the qualities he looks for in early stage companies and predicts AI's impact on real estate, credit, and energy.

Scale AI founder and CEO Alexandr Wang discusses the three pillars of AI—models, compute, and data—and how abundant data is core to the evolution of gen AI.

Nikita Singareddy, cofounder and CEO of Fortuna Health, joins Will Shrank, MD, a16z Bio + Health venture partner. This is the second episode in our Medicaid Matters series.

Anime is just getting started - today, new technologies and business models are accelerating a once niche industry to even greater heights.

In this post, we look at how AI is increasing VSaaS revenue per customer by enabling vertical SaaS companies to take on tasks previously too complex for software.

Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, our guests have long been laying the groundwork for innovations that are transforming industries today...

Over the next three episodes, we’re going to talk about why Medicaid matters, and the potential for technology to make it easier for enrollees to access and utilize the program. Our first guest is Mark Smith, MD, Clinical Professor of Medicine at UCSF.

Ambience cofounder Nikhil Buduma discusses how to build vertical applications with AI models, including in health care, and why tech expertise isn't enough.

This week in consumer tech: Apple’s big reveals, OpenAI’s multi-step reasoning, and Adobe Firefly’s video model.

Every white-collar role will have an AI copilot. Some of these roles will be fully automated with AI agents. 

When does virtual reality cease being virtual… and start to become reality? This episode digs deep into game design, philosophy, and mechanics with the maker of one of the world’s most iconic massive multiplayer online role playing games: EVE Online.

Vijay Pande, PhD, founding partner of a16z Bio + Health, joins Derrick Harris, host of the AI + a16z podcast.

Across the industries and companies that comprise American Dynamism, a decoupling of hardware and software for autonomy use cases is underway.

Discord Activities represents a significant opportunity for developers to create the next generation of web-based games.

Casey Means, MD, a Stanford-trained physician, cofounder of Levels, and author of the new book Good Energy, joins Vijay Pande, PhD, founding partner of a16z Bio + Health.

MotherDuck CEO Jordan Tigani discusses DuckDB's spiking popularity as the era of big data wanes, as well as the nexus of SQL and LLMs.

This month, the a16z fintech team went to Fintech DevCon, payments platform Moov’s annual conference for the fintech developer community.