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“Premature optimization is the root of all evil.”
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The RNA technology underlying both the Moderna and Pfizer/BioNTech vaccines could give us our fastest ticket out of the COVID-19 pandemic. With their rapid development and the early signs of success, RNA-based therapeuti...
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There’s been a lot of talk lately about possibilities for treating aging—from blood transfusions from old mice to young, to eradicating “zombie” cells, to taking daily rapamycin and metformin pills to extend your...
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The human brain is endlessly fascinating and mysterious, but the majority of brain research to date has focused on neurons and their functions. While the other types of brain cells, such as astrocytes and glia, are start...
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In Bio Eats World’s Journal Club episodes, we discuss groundbreaking research articles, why they matter, what new opportunities they present, and how to take these findings from paper to practice. In this episode, ...
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Eroom’s Law is Moore’s Law spelled backwards. It’s a term that was coined in a Nature Reviews Drug Discovery article by researchers at Sanford Bernstein and describes the exponential decrease in biopharma research ...
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Drug design is fundamentally a data science problem. Naturally, data science starts with the data, with a key challenge being the creation of accurate and highly reproducible data at scale. But data on its own are useles...
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The octant was the dominant tool for maritime navigation in the 18th century because it enabled sailors to chart an accurate course, even in pitching and rolling seas. Like seafaring, drug discovery is, at its core, exp...
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A deep dive into the world of drug development—specifically "undruggable drugs": a category of protein, protein family or even piece of RNA that’s so difficult to target that many researchers don’t even want to touch it—with Jay Bradner, President of the Novartis Institute for BioMedical Research.