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If the best way to know whether a medicine is effective is through a clinical trial, then where does (and doesn't) real-world data and real-world evidence come in? The topic is always top of mind in drug development, with additional focus as of 2016 thanks to the 21st Century Cures Act -- but is especially heated lately given recent concerns and claims around particular drugs in the context of the novel coronavirus pandemic. So in this short-but-deep dive episode of 16 Minutes on the News, a16z general partner in bio Vijay Pande -- previously a professor of Chemistry, Structural Biology, and Computer Science at Stanford University (as well as founder of Folding@Home) -- breaks down the debate between RWE vs. RCT (real world evidence and randomized controlled trials), in conversation with Sonal Chokshi.
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Every organization, whether small or big, early or late stage — and every individual, whether for themselves or others — makes countless decisions every day, under conditions of uncertainty. The question is, are we allowing that uncertainty to bubble to the surface, and if so, how much and when? Where does consensus, transparency, forecasting, backcasting, pre-mortems, and heck, even regret, usefully come in?
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As companies generally — and tech companies specifically — play a greater role in social and economic issues, the fundamental question that many consumers, politicians, and company builders are asking is, Do ...
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We already know that we have an innate tendency to anthropomorphize robots. But beyond just projecting human qualities onto them, as we begin to share more and more spaces, social and private, what kind of relationships ...
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Is it possible that ancient Greeks and Romans dreamed of technological innovations like robots and artificial intelligence millennia before those technologies became realities? In this episode of the a16z Podcast, Adrien...
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In this episode of the a16z Podcast, Johnson shares with a16z crypto general partner Chris Dixon and a16z’s Sonal Chokshi specific strategies — beyond good old-fashioned pro/con lists and post-mortems — for modeling the deliberative tactics of expert decision-makers (and not just oil-company scenario planners, but also storytellers). The decisions we’re talking about here aren’t just about individual lives and businesses — whether launching a new product feature or deciding where to innovate next — they’re also about even bigger and bolder things like how to fix the internet, or what message to send aliens with outcomes spanning centuries far into the future. But that’s where the power of story comes in again.
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There’s a lot of knowledge out there — and networks of talent (especially in Silicon Valley) — on what to do in the early stages of a company, going from 0 to 1, and even in going from 1 to 100… b...
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Given concern around data breaches, the EU Parliament finally passed GDPR (General Data Protection Regulation) after four years of preparation and debate; it goes into enforcement on May 25, 2018. Though it originated in...
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